5-Hydroxytryptamine induces forestomach hypomotility in sheep through 5-HT4 receptors
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5-Hydroxytryptamine receptors, especially the 5-HT4 receptor, in guinea pig urinary bladder.
The function of 5-hydroxytryptamine (5-HT) receptors, especially the 5-HT4 receptor, in the urinary bladder were examined in preparations isolated from the guinea pig by in vitro receptor autoradiography and determinations of mechanical activity and acetylcholine (ACh) release. Specific [125I]SB207710 binding sites were detected evenly throughout the urinary bladder. 5-HT (3 x 10(-8)-10(-4) M) ...
متن کامل5-Hydroxytryptamine induces phospholipase C-mediated hydrolysis of phosphoinositides through 5-hydroxytryptamine-2 receptors in cultured fetal mouse ventricular myocytes.
5-Hydroxytryptamine (5-HT) stimulates the rate and force of cardiac contraction. However, the molecular mechanisms of 5-HT actions on the heart are unknown. We examined effects of 5-HT on phospholipase C-mediated hydrolysis of phosphoinositides and its regulation in cultured fetal mouse ventricular myocytes labeled with [3H]inositol. Accumulation of inositol monophosphate, inositol bisphosphate...
متن کاملPropulsion in guinea pig colon induced by 5-hydroxytryptamine (HT) via 5-HT4 and 5-HT3 receptors.
Previous studies have shown that the intestinal peristaltic reflex initiated by mucosal stimulation is mediated by release of 5-hydroxytryptamine (HT) from enterochromaffin cells; 5-HT acts via 5-HT4 receptors in rat and human, and via both 5-HT4 and 5-HT3 receptors in guinea pig to activate intramural sensory neurons that release calcitonin gene-related peptide. In this study, selective agonis...
متن کامل5-HT induces duodenal mucosal bicarbonate secretion via cAMP- and Ca -dependent signaling pathways and 5-HT4 receptors in mice
Tuo, Bi-Guang, Zachary Sellers, Petra Paulus, Kim E. Barrett, and Jon I. Isenberg. 5-HT induces duodenal mucosal bicarbonate secretion via cAMPand Ca -dependent signaling pathways and 5-HT4 receptors in mice. Am J Physiol Gastrointest Liver Physiol 286: G444–G451, 2004. First published October 23, 2003; 10.1152/ ajpgi.00105.2003.—In previous studies, we have found that 5-hydroxytryptamine (5-HT...
متن کامل5-HT induces duodenal mucosal bicarbonate secretion via cAMP- and Ca2+-dependent signaling pathways and 5-HT4 receptors in mice.
In previous studies, we have found that 5-hydroxytryptamine (5-HT) is a potent stimulant of duodenal mucosal bicarbonate secretion (DMBS) in mice. The aim of the present study was to determine the intracellular signaling pathways and 5-HT receptor subtypes involved in 5-HT-induced DMBS. Bicarbonate secretion by murine duodenal mucosa was examined in vitro in Ussing chambers. 5-HT receptor invol...
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ژورنال
عنوان ژورنال: Experimental Physiology
سال: 1996
ISSN: 0958-0670
DOI: 10.1113/expphysiol.1996.sp003976